MicroRNAs (miRNAs) can regulate tumor cell invasion and metastasis in a tumor-specific manner.We recently demonstrated that global downregulation of miRNAs after deleting dicer can promote development of distant metastases in a mouse model of primary soft tissue sarcoma (STS).In this study, we identified miRNAs that are differentially Cardigans dow
An evaluation of a SVA retrotransposon in the FUS promoter as a transcriptional regulator and its association to ALS.
Genetic mutations of FUS have been linked to many diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration.A primate specific and polymorphic retrotransposon of the SINE-VNTR-Alu (SVA) family is present upstream of the FUS gene.Here we have BARLEY LIFE POWDER demonstrated that this retrotransposon can act as a cl
TAXONOMIC STRUCTURE OF PROKARYOTIC COMMUNITIES IN SOILS OF DIFFERENT BIOCLIMATIC ZONES
Using high-throughput sequencing, we performed a full-profile analysis of the taxonomic structure and diversity of prokaryotic communities of zonal soil series: sod-podzolic, dark gray, typical chernozem, brown soil, meadow-chestnut soil and solonets.Phyla Acidobacteria, Actinobacteria, Bacteroidetes, Chloroflexi, Firmicutes, Gemmatimonadetes, Plan
An alternative approach to wound healing field; new composite films from natural polymers for mupirocin dermal delivery
In this study, novel adhesive films were prepared for Mupirocin dermal delivery.Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release properties.Solvent evaporation method was used for films preparation.Preliminary studies involved FT-IR Sweeper spectroscopy and